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Jean Bennett Selected Research

Choroideremia

10/2022Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two-Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial.
1/2022Short-term Assessment of Subfoveal Injection of Adeno-Associated Virus-Mediated hCHM Gene Augmentation in Choroideremia Using Adaptive Optics Ophthalmoscopy.
10/2019Visual Function at the Atrophic Border in Choroideremia Assessed with Adaptive Optics Microperimetry.
1/2019Detailed retinal phenotype of Boucher-Neuhäuser syndrome associated with mutations in PNPLA6 mimicking choroideremia.
1/2018Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia.
1/2017Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study.
9/2014High-resolution adaptive optics retinal imaging of cellular structure in choroideremia.
5/2014Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models.
4/2003Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus.
3/2002Macular pigment and lutein supplementation in choroideremia.

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Jean Bennett Research Topics

Disease

15Retinal Degeneration
01/2022 - 08/2002
15Blindness (Hysterical Blindness)
01/2021 - 06/2003
11Retinal Diseases
10/2021 - 05/2003
11Leber Congenital Amaurosis
09/2018 - 01/2004
10Choroideremia
10/2022 - 03/2002
9Retinitis Pigmentosa (Pigmentary Retinopathy)
01/2022 - 01/2011
3Ganglion Cysts (Ganglion)
01/2021 - 12/2004
3Optic Nerve Diseases (Optic Neuropathy)
01/2021 - 01/2014
3Choroidal Neovascularization
04/2005 - 05/2003
2Retinal Perforations
10/2022 - 05/2008
2Cone-Rod Dystrophies
10/2018 - 12/2012
2Agenesis of Cerebellar Vermis
09/2018 - 10/2013
2Inflammation (Inflammations)
01/2018 - 08/2004
2Ciliopathies
01/2018 - 06/2015
2Disease Progression
09/2014 - 05/2013
1Peroxisome biogenesis disorders
12/2021
1Optic Nerve Injuries
01/2021
1Atrophy
01/2019
1Cone Dystrophy
01/2019
1Photophobia (Light Sensitivity)
01/2019
1Demyelinating Diseases (Demyelinating Disease)
01/2018
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2018
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2018
1Multiple Sclerosis
01/2018
1Opioid-Related Disorders (Opiate Addiction)
01/2018
1Optic Neuritis (Retrobulbar Neuritis)
01/2018
1Pain (Aches)
01/2018
1Epilepsy (Aura)
08/2017
1Infections
05/2014
1Meckel syndrome type 1
10/2013
1Senior Loken Syndrome
10/2013
1type 2 Amaurosis congenita of Leber
01/2013
1Macular Degeneration (Age-Related Maculopathy)
01/2011
1Retinal Dystrophies
09/2010
1Hydrocephalus (Hydrocephaly)
05/2007
1Pneumonia (Pneumonitis)
05/2007
1Hearing Loss (Hearing Impairment)
09/2006
1Vascular System Injuries
09/2005
1Diabetic Retinopathy (Retinopathy, Diabetic)
04/2005
1Macular Edema
04/2005
1Vision Disorders (Hemeralopia)
04/2004
1Stargardt Disease
03/2004
1Inborn Genetic Diseases (Disease, Hereditary)
07/2003
1Hypoxia (Hypoxemia)
05/2003
1Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy)
11/2002
1Retinopathy of Prematurity (Retrolental Fibroplasia)
10/2002

Drug/Important Bio-Agent (IBA)

35Retinaldehyde (Retinal)IBA
01/2022 - 04/2003
9Proteins (Proteins, Gene)FDA Link
01/2020 - 08/2004
3Complementary DNA (cDNA)IBA
10/2022 - 04/2005
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2005 - 05/2003
2Sirtuin 1IBA
01/2021 - 01/2018
2Pharmaceutical PreparationsIBA
01/2020 - 05/2013
2RNA Precursors (Precursor, mRNA)IBA
01/2019 - 09/2018
2Neuroprotective AgentsIBA
01/2018 - 11/2004
2Rhodopsin (Visual Purple)IBA
01/2015 - 04/2011
2Sirolimus (Rapamycin)FDA Link
12/2004 - 08/2002
2pigment epithelium-derived factorIBA
11/2004 - 10/2002
2Ceruloplasmin (Ferroxidase)IBA
08/2004 - 04/2003
1Indicators and Reagents (Reagents)IBA
01/2021
1TOR Serine-Threonine KinasesIBA
01/2019
1Insulin (Novolin)FDA Link
01/2019
1Opioid Analgesics (Opioids)IBA
01/2018
1Luxol Fast Blue MBS (Luxol fast blue)IBA
01/2018
1Eosine Yellowish-(YS) (Eosin)IBA
01/2018
1AntibodiesIBA
01/2018
1Hematoxylin (Haematoxylon)IBA
01/2018
1polyetheretherketoneIBA
01/2016
1DNA (Deoxyribonucleic Acid)IBA
11/2013
1Retinal Pigments (Pigments, Visual)IBA
01/2013
1Ammonium CompoundsIBA
07/2012
1azobenzeneIBA
07/2012
1Antisense OligonucleotidesIBA
03/2012
1Viral AntigensIBA
11/2005
1Oxygen (Dioxygen)IBA
09/2005
1RetinoidsIBA
04/2005
1N-Methylaspartate (NMDA)IBA
12/2004
1Therapeutic UsesIBA
11/2004
1PeripherinsIBA
11/2004
1Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
08/2004
1Transcription Factors (Transcription Factor)IBA
08/2004
1MetallothioneinIBA
08/2004
1OsteopontinIBA
08/2004
1AntioxidantsIBA
08/2004
1ChitinasesIBA
08/2004
1Chloride Channels (Chloride Channel)IBA
08/2004
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
03/2004
1SolutionsIBA
06/2003
1Dermatan SulfateIBA
11/2002
1EndostatinsIBA
10/2002
1Tissue Inhibitor of Metalloproteinase-3IBA
10/2002
1LuteinIBA
03/2002
1Macular PigmentIBA
03/2002

Therapy/Procedure

24Therapeutics
01/2022 - 08/2002
2Injections
10/2022 - 01/2022
2Intravitreal Injections
01/2021 - 12/2004
1Pain Management
01/2018
1Oral Surgery (Maxillofacial Surgery)
08/2017
1Stem Cell Transplantation
10/2016
1Cell Transplantation
10/2016
1Lasers (Laser)
05/2003